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This paper investigates a novel approach to improving indoor air quality and thermal comfort of laboratory facilities. Using Computational Fluid Dynamics (CFD), this study employs an advanced numerical simulation and empirical validation to assess the performance of active chilled beams in a general laboratory layout and the removal effectiveness of gases and airborne particles. Chilled beam performance is also compared to a ceiling diffuser system with and without cooling panels.The methodology and results of this study, which includes significant energy savings, may be applied to research for other laboratory types or climatic conditions.